Tuesday, January 31, 2012

Monty Python to reunite for new movie

Don't expect "Holy Grail Part II," but Python fans have the right to get excited anyway.

By Gael Fashingbauer Cooper

If you're a lumberjack and you're OK, ?recognize a dead parrot when you see one, and?know your way to the Ministry of Silly Walks,? you're going to want to read this. And then email and Tweet and Facebook it to all?your friends who also know every word to "The Ballad of Brave Sir Robin," and think of?themselves as card-carrying members of the Knights Who Say 'Ni!"

The surviving members of Monty Python?are reuniting for a new movie this spring, Variety reports.

Don't expect "Holy Grail Part II," however.

"It's not a Monty Python picture, but it certainly has that sensibility," Python Terry Jones, who helped develop the script and also will direct, told the magazine.

The Pythons will play mischievious aliens who grant an earthling the power to do anything he wants just to see what kind of mess ensues. Robin Williams provides the voice of a talking dog. (No, really.) According to Variety's report, Terry Gilliam, John Cleese and Michael Palin have signed on, and producers hope to sign Eric Idle. Graham Chapman died of cancer?in 1989.

Producer Mike Medavoy of "Black Swan" calls the film a "classic farce" and compares it to the "Pink Panther" movies. But he also adds that "like all projects originated by any of the Monty Python guys, 'Absolutely Anything' delightfully defies (description)."

After all, nooooo one expects a Monty Python reunion.

Will you see this film, or isn't it Python enough for your tastes? And what's your absolute favorite quote or skit from the troupe? Tell us on Facebook.

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Source: http://entertainment.msnbc.msn.com/_news/2012/01/31/10273222-monty-python-to-reunite-for-new-movie

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Monday, January 30, 2012

UN nuclear officials want Iranian cooperation (AP)

VIENNA ? The head of a U.N. nuclear team traveling to Iran say he hopes the country will work with his mission on probing Tehran's alleged attempts to develop an atomic arms program, adding such cooperation is long overdue.

Herman Nackaerts says "we hope that Iran will engage with us on all concerns regarding a possible military dimension of Iran's nuclear program."

He says his team is "looking forward to the start of a dialogue ? a dialogue that is overdue since very long."

Nackaerts spoke Saturday as his team arrived at Vienna's airport for a flight to Tehran.

Iran has for years dismissed suspicions that it worked in secret on components of a weapons program. Diplomats say it has signaled willingness to discuss all issues with the International Atomic Energy Agency team, but they are skeptical of a breakthrough.

Source: http://us.rd.yahoo.com/dailynews/rss/europe/*http%3A//news.yahoo.com/s/ap/20120128/ap_on_re_eu/iran_nuclear

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Sunday, January 29, 2012

Romney widens lead over Gingrich in Florida: poll (Reuters)

WASHINGTON (Reuters) ? White House hopeful Mitt Romney widened his lead over rival Newt Gingrich to 11 percentage points in Florida, according to Reuters/Ipsos online poll results on Saturday, up from 8 points a day earlier, as he cemented his front-runner status in the Republican nomination race.

With just three days remaining before Florida's Republican primary, Romney, a former Massachusetts governor, led Gingrich, a former speaker of the U.S. House of Representatives, by 43 percent to 32 percent among likely voters in Florida's January 31 primary, the online poll said.

He had led Gingrich by 41 percent to 33 percent in the online tracking poll on Friday.

"The momentum in Florida ... really seems to be moving in Romney's direction," said Chris Jackson, research director for Ipsos Public Affairs.

The poll confirmed that Romney's fortunes are turning around in Florida a week after a stinging setback when Gingrich scored an upset win in South Carolina's primary.

Romney has moved ahead of Gingrich in several Florida polls, after turning in his strongest debate performance yet in the seesawing race for the Republican nomination to oppose Democratic President Barack Obama's bid for re-election in November.

The Reuters/Ipsos survey showed Romney also gained when voters were asked who they would support in a head-to-head contest with Gingrich. Saturday's results showed that 53 percent would support him, versus 45 percent for Gingrich.

In the results released on Friday, Romney had led by just 2 percentage points when voters were asked the same question.

SANTORUM GETTING SOME GINGRICH SUPPORT?

Former Pennsylvania Senator Rick Santorum trailed well behind with 16 percent support, but he had gained ground from 13 percent in Friday's results.

"It seems like some people who are leaving Gingrich are moving to the other conservative in the race, Rick Santorum," Jackson said.

Texas Congressman Ron Paul was at 6 percent, up from 5 percent. The small-government libertarian has not been campaigning in Florida.

Romney has subjected Gingrich to a blistering run of attack advertisements in Florida. He has assailed Gingrich for leaving Congress under an ethics cloud in the 1990s and for being a Washington insider and lobbyist in the two decades since.

Gingrich denies he ever worked as a lobbyist, but has yet to find an effective way to parry Romney's attacks.

The Reuters/Ipsos poll was conducted on Thursday, Friday and Saturday, capturing many voters after the most recent debate in Jacksonville on Thursday, where Romney was seen as a clear winner.

Florida lets voters cast their ballots early at polling stations or by mail, and 30 percent of the poll respondents said they had done so, compared with 29 percent on Friday.

Romney held a 12-point lead among those who had already voted, and an 11-point lead among those who had not yet voted.

Statistical margins of error are not applicable to online surveys, but this poll of 903 likely voters has a credibility interval of plus or minus 4 percentage points.

Saturday's Reuters/Ipsos survey is the second of four daily tracking polls being released ahead of Tuesday's Florida primary.

(Editing by Mohammad Zargham)

Source: http://us.rd.yahoo.com/dailynews/rss/gop/*http%3A//news.yahoo.com/s/nm/20120129/pl_nm/us_usa_campaign_poll

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Saturday, January 28, 2012

AP Exclusive: Barrier proposed as Israel border (AP)

RAMALLAH, West Bank ? Israel is proposing to essentially turn its West Bank separation barrier into the border with a future state of Palestine, two Palestinian officials said Friday, based on their interpretation of principles Israel presented in talks this week.

The officials said Israeli envoy Yitzak Molcho told his Palestinian counterpart that Israel wants to keep east Jerusalem and consolidate Jewish settlements behind the separation barrier, which slices close to 10 percent off the West Bank. They spoke on condition of anonymity, citing strict no-leaks rules by Jordanian mediators.

The proposal would fall short of what the Palestinians seem likely to accept, especially because it would leave Jerusalem on the "Israeli" side of the border.

But it would also mark a significant step for Israeli Prime Minister Benjamin Netanyahu, who has spent most of his career as a staunch opponent of Palestinian independence.

And if talks advance in such a direction, it could also spell the end for his nationalist coalition, where key members would consider the abandonment of most of the West Bank ? a strategic highland and biblical heartland ? an unforgivable betrayal.

Israel has confirmed that it presented principles this week for drawing a border with a Palestinian state. But the politically charged nature of the talks ? even though they were held at a relatively low level, below that of Cabinet ministers ? was reflected in the guarded refusal by any top official to discuss details.

An Israeli government official said that as far as he knew, the information was incorrect, but declined to elaborate or go on the record, citing Jordan's demand for discretion.

Deputy Prime Minister Dan Meridor, one of the closest Cabinet ministers to Netanyahu, said he has been supporting such an offer for months, and that Israel should concentrate on preserving the large West Bank settlement blocs, close to the pre-1967 border. But he could not confirm whether the offer was in fact made.

"I do not know if (Molcho) said these words exactly, but it would be great," Meridor told The Associated Press.

The Palestinian officials ? one a senior member of the leadership ? said Molcho told the Palestinians that Israel wants to leave peacefully beside a Palestinian state.

It would be the most detailed offer yet from Netanyahu on how much he wants to keep of the lands Israel captured in the 1967 Mideast War ? the West Bank, Gaza and east Jerusalem.

The Palestinians want to establish their state in virtually all of these lands ? although they do seem ready to accept minor adjustments, through land swaps in which Israel keeps some of the largest settlements.

Palestinian President Mahmoud Abbas is certainly unlikely to consider a proposal that keeps east Jerusalem under Israeli control. The eastern sector of the city is home to key Jewish, Muslim and Christian sites.

And Israel's position, as described by the Palestinians, is less than what was offered by Netanyahu's predecessors, Ehud Barak and Ehud Olmert, who were willing to discuss a partition of Jerusalem as well.

About half a million Israelis settled in east Jerusalem and the West Bank after 1967, including tens of thousands east of the barrier.

Israel started building the barrier in 2002, in the midst of a Palestinian uprising that included scores of deadly attacks by Palestinian militants who crossed from the West Bank into Israel and blew themselves up among civilians.

Israelis have generally credited the barrier ? along with other punitive measures ? with stopping the spate of incursions several years ago.

However, it was routed in a way that raised questions about Israel's claim that it was a temporary security measure ? weaving through the West Bank, looping wide around some settlements to leave room for expansion, and looking very much like a border a future Israeli government might argue for. The Palestinians condemned it from the start as a land grab.

The Palestinian officials also said that Molcho portrayed the Jordan Valley, which makes up about one-fourth of the West Bank and borders Jordan, as a strategic Israeli security asset. However, that wording suggests less than a demand for firm territorial control.

Netanyahu has said he wants a continued Israeli presence on the eastern border of a future Palestinian state as part of any peace deal.

Netanyahu has long argued Israel needs the area as a security buffer ? protection against possible attack from the east.

The 1994 peace treaty with Jordan eased this concern ? but the Arab Spring has given it new life: although it is almost never discussed by officials, mindful of riling Jordan, many in Israel ponder a nightmare scenario in which the Jordanian monarchy falls to Israel's enemies, who then pour weapons and militants into the West Bank, reaching within miles (kilometers) from its major cities.

A senior Israeli military official said last week the Israeli army had to consider in its planning the possibility of heightened threats from east of the West Bank.

Israeli officials have said any presence in the Jordan Valley could be reviewed over time.

Abbas, meanwhile, is under growing pressure from the Quartet of Mideast mediators ? the U.S., the U.N., the EU and Russia ? to continue the talks with Israel, which began earlier this month. The Quartet had asked the sides to present detailed proposals on borders and security arrangements.

The Palestinians argue that the period set aside for the contacts ended Thursday, or three months after the Quartet issued its marching orders. Israel says the intention was to have three months of talks, and so wants meetings to continue.

Abbas will consult Monday with senior officials from the Palestine Liberation Organization and his Fatah movement. Later next week, he will also seek advice from the Arab League.

___

Perry reported from Tel Aviv, Israel.

Source: http://us.rd.yahoo.com/dailynews/rss/mideast/*http%3A//news.yahoo.com/s/ap/20120127/ap_on_re_mi_ea/ml_israel_palestinians

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Friday, January 27, 2012

Mitt Romney's Tax Returns, Like Those Of Biden, Bush, Etc., Offer Clues To Character

The tax returns of prominent officeholders are scrutinized not just for details about the individuals' financial lives, but for clues about their character. Mitt Romney's returns, released Tuesday after weeks of pressure from his rivals for the Republican presidential nomination, have been eyeballed more closely than an eighth-grade boy's first pornographic magazine. The returns reveal, as expected, an extremely wealthy individual who benefits enormously from the lower tax rate on investment income.

One can certainly draw conclusions about Romney's character from his statements about that tax rate, which indicate he thinks he is paying his fair share. But the returns also suggest piety: Romney and his wife, Ann, donated more than $4 million in 2010 and 2011 to the Mormon church -- a 10 percent tithe on their more than $40 million in adjusted gross income for those years.

A Huffington Post review of the past tax filings of presidents and vice presidents turned up other details that may help provide a better understanding of the people behind the numbers.

Vice President Joe Biden and his wife, Jill, have cleaned house, it seems. In their 2010 tax return, the Bidens say they donated $3,800 in "clothing and household goods" with a fair market value of $950 to a Goodwill site in Wilmington, Del.

Ted Sikorski, a Goodwill spokesman, said that Wilmington area stores receive 400,000 donations a year and that the organization doesn't keep track of who donates what, so there is no telling whether those donations included Jill Biden's vintage dresses or Joe Biden's old gym socks. But if you bought a pair of pants from a Delaware Goodwill store recently and found an Amtrak ticket stub in the pocket -- well, who knows.

That the Bidens bothered to claim such a small tax write-off says something about their finances. They reported adjusted gross income of $379,178 in 2010 -- a nice payday for most Americans, but considerably less than many members of Congress, and also less than Joe Biden's boss and his wife, who earned $1,728,096 in 2010. That was, in turn, considerably less than the $5.5 million that Barack and Michelle Obama reported in 2009, mostly from book sales.

In 1969, Richard Nixon claimed a $576,000 deduction for donating his own papers to the government -- a tax trick that likely wouldn't fly today, at least not politically. According to the inventory included with the return, those papers included "15,000 items from the visit to the United States of Soviet premier Nikita Khrushchev."

Other tidbits: In 1983, Ronald and Nancy Reagan reported $3,300 in rent collected from a radio station that operated on vacant land he owned near his beloved Santa Barbara, Calif., ranch. Bill and Hillary Clinton claimed a deduction on $38,683 in moving expenses in 1993, the year they moved from Arkansas to the White House. Barbara Bush earned a $1,000 "signer's fee" from Reader's Digest in 1990, according to the tax return jointly filed with George H.W. Bush.

The most revealing return, reflecting both a different age of presidential prerogative and still-current themes of a tax system that befuddles most filers, came from Franklin Roosevelt. In 1937, he reported $82,392 in net income, but couldn't figure out how much to pay. His solution: he sent a $15,000 check and a letter to the commissioner of the Internal Revenue Service.

"I am wholly unable to figure out the amount of the tax for the following reasons," Roosevelt wrote before launching into an explanation of how tax rates had changed the prior year. "As this is a problem in higher mathematics, may I ask that the Bureau let me know the amount of the balance due?" he concluded.

Romney's 2010 tax return, longer than any past president's at 203 pages, shows he isn't willing to trust the government to tell him what he owes.

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Source: http://www.huffingtonpost.com/2012/01/26/mitt-romney-tax-returns-clues-character_n_1233772.html

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No energy industry backing for the word 'fracking' (AP)

NEW YORK ? A different kind of F-word is stirring a linguistic and political debate as controversial as what it defines.

The word is "fracking" ? as in hydraulic fracturing, a technique long used by the oil and gas industry to free oil and gas from rock.

It's not in the dictionary, the industry hates it, and President Barack Obama didn't use it in his State of the Union speech ? even as he praised federal subsidies for it.

The word sounds nasty, and environmental advocates have been able to use it to generate opposition ? and revulsion ? to what they say is a nasty process that threatens water supplies.

"It obviously calls to mind other less socially polite terms, and folks have been able to take advantage of that," said Kate Sinding, a senior attorney at the Natural Resources Defense Council who works on drilling issues.

One of the chants at an anti-drilling rally in Albany earlier this month was "No fracking way!"

Industry executives argue that the word is deliberately misspelled by environmental activists and that it has become a slur that should not be used by media outlets that strive for objectivity.

"It's a co-opted word and a co-opted spelling used to make it look as offensive as people can try to make it look," said Michael Kehs, vice president for Strategic Affairs at Chesapeake Energy, the nation's second-largest natural gas producer.

To the surviving humans of the sci-fi TV series "Battlestar Galactica," it has nothing to do with oil and gas. It is used as a substitute for the very down-to-Earth curse word.

Michael Weiss, a professor of linguistics at Cornell University, says the word originated as simple industry jargon, but has taken on a negative meaning over time ? much like the word "silly" once meant "holy."

But "frack" also happens to sound like "smack" and "whack," with more violent connotations.

"When you hear the word `fracking,' what lights up your brain is the profanity," says Deborah Mitchell, who teaches marketing at the University of Wisconsin's School of Business. "Negative things come to mind."

Obama did not use the word in his State of the Union address Tuesday night, when he said his administration will help ensure natural gas will be developed safely, suggesting it would support 600,000 jobs by the end of the decade.

In hydraulic fracturing, millions of gallons of water, sand and chemicals are pumped into wells to break up underground rock formations and create escape routes for the oil and gas. In recent years, the industry has learned to combine the practice with the ability to drill horizontally into beds of shale, layers of fine-grained rock that in some cases have trapped ancient organic matter that has cooked into oil and gas.

By doing so, drillers have unlocked natural gas deposits across the East, South and Midwest that are large enough to supply the U.S. for decades. Natural gas prices have dipped to decade-low levels, reducing customer bills and prompting manufacturers who depend on the fuel to expand operations in the U.S.

Environmentalists worry that the fluid could leak into water supplies from cracked casings in wells. They are also concerned that wastewater from the process could contaminate water supplies if not properly treated or disposed of. And they worry the method allows too much methane, the main component of natural gas and an extraordinarily potent greenhouse gas, to escape.

Some want to ban the practice altogether, while others want tighter regulations.

The Environmental Protection Agency is studying the issue and may propose federal regulations. The industry prefers that states regulate the process.

Some states have banned it. A New York proposal to lift its ban drew about 40,000 public comments ? an unprecedented total ? inspired in part by slogans such as "Don't Frack With New York."

The drilling industry has generally spelled the word without a "K," using terms like "frac job" or "frac fluid."

Energy historian Daniel Yergin spells it "fraccing" in his book, "The Quest: Energy, Security and the Remaking of the Modern World." The glossary maintained by the oilfield services company Schlumberger includes only "frac" and "hydraulic fracturing."

The spelling of "fracking" began appearing in the media and in oil and gas company materials long before the process became controversial. It first was used in an Associated Press story in 1981. That same year, an oil and gas company called Velvet Exploration, based in British Columbia, issued a press release that detailed its plans to complete "fracking" a well.

The word was used in trade journals throughout the 1980s. In 1990, Commerce Secretary Robert Mosbacher announced U.S. oil engineers would travel to the Soviet Union to share drilling technology, including fracking.

The word does not appear in The Associated Press Stylebook, a guide for news organizations. David Minthorn, deputy standards editor at the AP, says there are tentative plans to include an entry in the 2012 edition.

He said the current standard is to avoid using the word except in direct quotes, and to instead use "hydraulic fracturing."

That won't stop activists ? sometimes called "fracktivists" ? from repeating the word as often as possible.

"It was created by the industry, and the industry is going to have to live with it," says the NRDC's Sinding.

Dave McCurdy, CEO of the American Gas Association, agrees, much to his dismay: "It's Madison Avenue hell," he says.

___

Jonathan Fahey can be reached at http://twitter.com/JonathanFahey.

Source: http://us.rd.yahoo.com/dailynews/rss/energy/*http%3A//news.yahoo.com/s/ap/20120126/ap_on_bi_ge/us_fracking

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Thursday, January 26, 2012

Conoco says reaches China spill compensation deal (AP)

BEIJING ? ConocoPhillips said Wednesday that it and China National Offshore Oil Corp. reached a $160 million agreement to settle compensation claims from oil spills off northeastern China.

The Houston-based company said in a statement that the two had reached an agreement with China's Ministry of Agriculture over the oil spills last June in the Bohai Sea.

The spills were considered small, especially compared with the Gulf of Mexico spills in 2010, but Conoco, the operator of the Bohai field, still came under intense media criticism in China.

Conoco said the money, 1 billion yuan, would be used "to settle public and private claims of potentially affected fishermen in relevant Bohai Bay communities."

It said 10 percent of the money would go to the company's previously announced fund to improve fishery resources.

The agreement will likely stop a lawsuit that a group of more than 100 Chinese fishermen filed last year seeking compensation from ConocoPhillips China for damage to their sea cucumber catches.

In September, ConocoPhillips announced plans to set up two funds to pay compensation and address environmental problems resulting from the spills.

The government has already ordered the company to stop all production pending a full cleanup and a review to ensure no more oil seeps into the sea.

The oil spill covered about 2,500 square miles (6,200 sq. kilometers) of water surface. It drew attention to pollution in the Bohai region due to industrialization, oil drilling and fast population growth that has decimated sea food and fish stocks and caused frequent red tides.

Sea cucumbers, one of many types of sea product harvested in the Bohai, are sausage-shaped, often spiky marine animals that are viewed as a delicacy by many in Asia.

Source: http://us.rd.yahoo.com/dailynews/rss/environment/*http%3A//news.yahoo.com/s/ap/20120125/ap_on_bi_ge/as_china_oil_spill

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The View Inside The Costa Concordia Makes My Head Spin [Image Cache]

Since the Costa Concordia ran aground in Italy, it's been listing at an incredible angle, almost sitting on its side. It looks weird enough from the outside, but images taken by the Italian Navy make my head hurt. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/IoU4yljvI8Q/the-view-inside-the-costa-concordia-makes-my-head-spin

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Wednesday, January 25, 2012

UN's new Afghan envoy heartened by talk of peace (AP)

KABUL, Afghanistan ? The U.N.'s new representative to war-torn Afghanistan said Wednesday that he was encouraged by widespread discussion about prospects for making peace with the Taliban.

Jan Kubis, the new special representative of the U.N. Secretary-General, said that he thinks the Afghan people are tired of the 10-year war and are interested in supporting steps that would bring more stability and eventually peace to Afghanistan.

"Political forces are discussing it. The parliament is discussing it. Civil society is discussing it at all levels ? not only at the top level, but in the provinces," said Kubis, who arrived in Afghanistan about a week ago and has been meeting with Afghan President Hamid Karzai and other top Afghan and international officials. "People are trying to understand what can we do to support this."

The U.S. has engaged in secret talks with Taliban figures, and the Afghan government and other regional players have also opened lines of communication with the insurgency as a way to find a political resolution to the war.

Kubis said that no major, relevant party can be excluded from the discussion.

He cautioned that the country was still dangerous.

"It's obvious to everyone that the security situation is still volatile," Kubis said. "Unfortunately, suicide and terrorist attacks are a part of the life here. What is tragic and sad is that unfortunately, suicide attacks are targeting, indiscriminately, civilians, including children and women.

Kubis succeeds Staffan de Mistura, who headed the United National Assistance Mission in Afghanistan from March 2010 to December 2011. Prior to taking up his new position, Kubis was executive secretary of the U.N. Economic Commission for Europe.

He said his priorities were to link security and development, promote reconciliation and work on issues related to governance, human rights, election and legal reforms.

Kubis arrives as international development assistance is declining and foreign combat forces have started to withdraw ? a gradual process that is to be completed by the end of 2014.

Some countries, including France, are under domestic political pressure to pull out of the unpopular war early.

France halted its training programs for the Afghan military and threatened to withdraw its forces earlier than planned after an Afghan soldier shot and killed four French troops last week in eastern Afghanistan.

Defense Ministry Gen. Mohammad Zahir Azimi said Wednesday that an investigation is ongoing into the attack. He would not confirm speculation the attack was motivated by a video purporting to show U.S. Marines desecrating Taliban insurgents' bodies, or for some other reason.

He said the Afghan soldier, who is in custody, is 21 years old and had been in the Afghan National Army less than three months.

"Our initial investigation is not completely clear," Azimi said.

The 39-second video, which showed what appeared to be Marines urinating on the corpses of Afghans, drew immediate condemnation from all sides when it surfaced on YouTube earlier this month.

The attack was latest of several by an Afghan soldier on international troops working with the national army. There have been more than a dozen such turncoat attacks in two years, although the U.S.-led coalition says they are isolated incidents that do not point to a wider trend nor to organized Taliban infiltration.

The U.S. military promised to investigate and punish those involved, but the video's wide distribution has threatened to sour relations between Afghans and the international troops working to train the national army to take over security by the end of 2014.

French investigators are traveling to Afghanistan to assist in investigating the attack.

___

Associated Press Writer Kay Johnson and Massieh Neshat in Kabul contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20120125/ap_on_re_as/as_afghanistan

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Fixing the budget means higher taxes

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If we really are going to reduce the federal deficit, new tax revenues must be part of the solution.


Source: http://rss.csmonitor.com/~r/feeds/csm/~3/TshLdNpTKws/Fixing-the-budget-means-higher-taxes

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Monday, January 23, 2012

Forecast: Seattle weather could stay eventful in next three months

Forecasters looking at temperature and precipitation trends are calling for cooler and wetter conditions than normal in the Pacific Northwest. Seattle weather this week has consisted of snow and ice storms.

If this week's snow and ice storms have left you sleepless in Seattle, break out the waders, if not the snowshoes.

Skip to next paragraph

Federal forecasters looking at temperature and precipitation trends over the next three months are calling for cooler and wetter conditions than normal in the Pacific Northwest.

Indeed, over the next 14 days, the western United States is expected to be the country's ground zero for a range of hazardous conditions ? from heavy snow in the northern Rockies to high winds throughout most of the region to heavy rains for the Pacific Coast, from just north of San Luis Obispo, Calif., to Seattle and beyond.

For the rest of the country, up to two-thirds of the Lower 48, from Arizona to the East Coast, is expected to be warmer than normal. Much of the Upper Midwest and Ohio River Valley is in the wetter-then-normal zone, while drier than normal remains the order of the season for the southern tier ? already experiencing severe, prolonged drought.

Does this have a vaguely familiar ring to it? It's a general pattern the country experienced last winter, as La Ni?a also made its presence felt. La Ni?a is the cool half of a periodic swing in ocean-surface temperatures across the tropical Pacific.

While the effects of La Ni?a, and its warm alter ego El Ni?o, are most acute in the tropics, these changes affect atmospheric circulation patterns at higher latitudes as well.

La Ni?a tends to force the average track that storms take across North America farther north than usual, drying out the southern US while dumping rain and snow across the Pacific Northwest, Midwest, and Northeast.

Currently, forecast models indicate La Ni?a will weaken "as we get into the middle of spring," notes Ed O'Lenic, who heads the operations branch at the National Oceanic and Atmospheric Administration's Climate Prediction Center in Camp Springs, Md.

Those forecasts came as NOAA unveiled its initial weather-and-climate year in review for 2011.

Record tornado outbreaks last spring; searing summer temperatures and withering drought in Texas, New Mexico, Oklahoma, and Louisiana; and torrential downpours from hurricane Irene and tropical storm Lee helped rack up more than $55 billion in damage in 2011.

"2011 was an extraordinary year," said Kathryn Sullivan, assistant secretary of Commerce for environmental prediction, at a briefing Thursday. Moreover, tropical storm Lee and a severe-weather outbreak in July in the Rockies and Upper Plains have only recently been added to the list of events that inflicted more than $1 billion in damage last year.

Officials are looking at last Halloween's snowstorm in the Northeast to see if it also needs to be added, she said.

While NOAA officials are reluctant to attribute the various outbreaks of severe weather in 2011 to global warming, longer-term temperature patterns are emerging that they say are consistent with model projections of a warming climate as carbon-dioxide emissions from human industrial activities and land-use changes increase.

Last year marked the 15th consecutive year with a national average temperature for the year above normal, with much of the warmth coming from increases in nighttime low temperatures.

"That's consistent with the increase in temperatures" globally, said Thomas Karl, who heads NOAA's National Climatic Data Center (NCDC) in Asheville, N.C.

The data also show that the proportion of the country affected either by extremely dry or extremely wet conditions in a given year has expanded.

Since a 20th-century low of about 3 percent in 1970, the extent of the country affected each year by either of these two conditions has climbed unsteadily to a record 58 percent last year. The average for the 20th century is just over 20 percent.

Globally, 2011 tied 2008 as the second coolest year so far this century, which still boasts nine of the 10 warmest years on record ? including the warmest (2005 and 2010). But measured against the 20th-century records, 2011 would find itself in a tie as the second-warmest year on record. It ties for the 11th warmest since 1880.

Climate researchers have noted that a generally warming climate will still have its natural swings, such as the El Ni?o and La Ni?a cycles. But their effects would be superimposed over the longer-term warming trend.

That pattern emerges in NOAA's data tracking temperatures during El Ni?o and La Ni?a years, as well as during what Deke Arndt, who heads the NCDC's climate monitoring branch, dubs the "La Nada" years, when conditions are neutral.

Since the 1980s, El Ni?o years have undergone their own warming trend, as have La Ni?a years.

As the US heads into midwinter, at least one climate factor has kept last year's deep chill from the Deep South again. The Arctic Oscillation, another kind of natural climate swing, has been in a strong positive phase so far ? generating pole-circling winds strong enough to keep cold arctic air from plunging deep into the continental interior.

For now, forecasters expect the Arctic Oscillation to remain positive, bringing temperatures a bit warmer than normal to the north-central US, says Mr. O'Lenic.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/x68TYIQqgnI/Forecast-Seattle-weather-could-stay-eventful-in-next-three-months

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Sandusky says Paterno's death is a sad day (AP)

STATE COLLEGE, Pa. ? Retired Penn State assistant coach Jerry Sandusky, who faces child sex abuse charges in a case that led to the firing of Joe Paterno, says Paterno's death is a sad day.

Sandusky says no one did more for the university's academic reputation than Paterno, who died Sunday. He says the longtime coach "had the courage to practice what he preached" about toughness, hard work and clean competition. He also expresses sympathy to Paterno's family.

Sandusky is awaiting trial on 52 criminal counts for what prosecutors say was sexual abuse of 10 children over 15 years. He denies the allegations.

Sandusky was Paterno's top assistant for years until he retired in 1999. Sandusky says he remembers Paterno as a great man who met high standards in a difficult job.

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/ap/20120122/ap_on_sp_co_ne/fbc_paterno_sandusky

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Sunday, January 22, 2012

97% The Artist

"The Artist" celebrates the absolute best part of cinema, the era in which sound came into the picture. As George Valentin is stripped away from his passion, he meets a young women who is about to become the newest celebrity in hollywood. Until the finding of sound in film, it seems as though the industry has taken a sort of downward spiral. By the end of the film you will be cheering, but the one problem I faced during the film, is that this story has been done to death before. A classic film known as "Singing in the Rain" has a very similar story to tell. That being said, the performances are stupendous, the score is oscar worthy, the film pays a beautiful homage to classic cinema, and the screenwriters really took a chance with this film, succeeding with flying colours. I love "The Artist," and the interconnecting romance was superb, but I wish it had been done a little differently. Still, this film deserves a nomination. One of the best of 2011!

January 21, 2012

Source: http://www.rottentomatoes.com/m/the_artist/

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iConvert hardware scanner for iPad coming in February

iConvert is set to launch an iPad specific hardware scanner in February. The scanner has been designed for the road warrior that no longer wants or needs to carry around a laptop, but needs to regularly scan documents on the go .


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/h_Xidvpq0lE/story01.htm

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Saturday, January 21, 2012

Legendary blues singer Etta James dies in Calif.

FILE - This Nov. 24, 2008 file photo Etta James arrives at the premiere of "Cadillac Records" in Los Angeles. James, the feisty rhythm and blues singer whose raw, passionate vocals anchored many hits and made the yearning ballad "At Last" an enduring anthem for weddings, commercials and even President Barack Obama, died Friday, Jan. 20, 2012. She was 73. James had been suffering from dementia and kidney problems, and was battling leukemia. In December 2011, her physician announced that her leukemia was terminal. (AP Photo/Matt Sayles, File)

FILE - This Nov. 24, 2008 file photo Etta James arrives at the premiere of "Cadillac Records" in Los Angeles. James, the feisty rhythm and blues singer whose raw, passionate vocals anchored many hits and made the yearning ballad "At Last" an enduring anthem for weddings, commercials and even President Barack Obama, died Friday, Jan. 20, 2012. She was 73. James had been suffering from dementia and kidney problems, and was battling leukemia. In December 2011, her physician announced that her leukemia was terminal. (AP Photo/Matt Sayles, File)

In this, April 6, 1987, photo, singer Etta James performs at the Vine St. Bar & Grill in Hollywood, Calif. The singer's manager says Etta James has died in Southern California. Lupe De Leon tells The Associated Press the singer died early Friday, Jan. 20, 2012 at Riverside Community Hospital. De Leon says the cause of death is complications of leukemia. (AP PhotoAlison Wise)

FILE - In this Saturday, June 19, 2004, photo, Etta James & The Roots Band perform at the 26th annual Playboy Jazz Festival at the Hollywood Bowl in Los Angeles. The singer's manager says Etta James has died in Southern California. Lupe De Leon tells The Associated Press the singer died early Friday, Jan. 20, 2012 at Riverside Community Hospital. De Leon says the cause of death is complications of leukemia. (AP Photo/Damian Dovarganes)

FILE - In this Friday, April 18, 2003, photo, legendary singer Etta James points to her star after an unveiling ceremony on the Walk of Fame, in the Hollywood section of Los Angeles. The singer's manager says Etta James has died in Southern California. Lupe De Leon tells The Associated Press the singer died early Friday, Jan. 20, 2012 at Riverside Community Hospital. De Leon says the cause of death is complications of leukemia. (AP Photo/Nick Ut)

FILE - In this Jan. 13, 1993, photo, singer Etta James, left, gets a hug from fellow singer K d Lang as she is inducted to the Rock and Roll hall fame, in Los Angeles. The singer's manager says Etta James has died in Southern California. Lupe De Leon tells The Associated Press the singer died early Friday, Jan. 20, 2012 at Riverside Community Hospital. De Leon says the cause of death is complications of leukemia. (AP Photo/Kevork Djansezian)

(AP) ? Etta James' performance of the enduring classic "At Last" was the embodiment of refined soul: Angelic-sounding strings harkened the arrival of her passionate yet measured vocals as she sang tenderly about a love finally realized after a long and patient wait.

In real life, little about James was as genteel as that song. The platinum blonde's first hit was a saucy R&B number about sex, and she was known as a hell-raiser who had tempestuous relationships with her family, her men and the music industry. Then she spent years battling a drug addiction that she admitted sapped away at her great talents.

The 73-year-old died on Friday at Riverside Community Hospital from complications of leukemia, with her husband and sons at her side, her manager, Lupe De Leon said.

"It's a tremendous loss for her fans around the world," he said. "She'll be missed. A great American singer. Her music defied category."

James' spirit could not be contained ? perhaps that's what made her so magnetic in music; it is surely what made her so dynamic as one of R&B, blues and rock 'n' roll's underrated legends.

"The bad girls ... had the look that I liked," she wrote in her 1995 autobiography, "Rage to Survive." ''I wanted to be rare, I wanted to be noticed, I wanted to be exotic as a Cotton Club chorus girl, and I wanted to be obvious as the most flamboyant hooker on the street. I just wanted to be."

"Etta James was a pioneer. Her ever-changing sound has influenced rock and roll, rhythm and blues, pop, soul and jazz artists, marking her place as one of the most important female artists of our time," said Rock and Roll Hall of Fame President and CEO Terry Stewart. "From Janis Joplin to Joss Stone, an incredible number of performers owe their debts to her. There is no mistaking the voice of Etta James, and it will live forever."

Despite the reputation she cultivated, she would always be remembered best for "At Last." The jazz-inflected rendition wasn't the original, but it would become the most famous and the song that would define her as a legendary singer. Over the decades, brides used it as their song down the aisle and car companies to hawk their wares, and it filtered from one generation to the next through its inclusion in movies like "American Pie." Perhaps most famously, President Obama and the first lady danced to a version at his inauguration ball.

The tender, sweet song belied the turmoil in her personal life. James ? born Jamesetta Hawkins ? was born in Los Angeles to a mother whom she described as a scam artist, a substance abuser and a fleeting presence during her youth. She never knew her father, although she was told and had believed, that he was the famous billiards player Minnesota Fats. He neither confirmed nor denied it: when they met, he simply told her: "I don't remember everything. I wish I did, but I don't."

She was raised by Lula and Jesse Rogers, who owned the rooming house where her mother once lived in. The pair brought up James in the Christian faith, and as a young girl, her voice stood out in the church choir. James landed the solos in the choir and became so well known, she said that Hollywood stars would come to see her perform.

But she wouldn't stay a gospel singer for long. Rhythm and blues lured her away from the church, and she found herself drawn to the grittiness of the music.

"My mother always wanted me to be a jazz singer, but I always wanted to be raunchy," she recalled in her book.

She was doing just that when bandleader Johnny Otis found her singing on San Francisco street corners with some girlfriends in the early 1950s. Otis, a legend in his own right, died on Tuesday.

"At the time, Hank Ballard and the Midnighters had a hit with 'Work With Me, Annie,' and we decided to do an answer. We didn't think we would get in show business, we were just running around making up answers to songs," James told The Associated Press in 1987.

And so they replied with the song, "Roll With Me, Henry."

When Otis heard it, he told James to get her mother's permission to accompany him to Los Angeles to make a recording. Instead, the 15-year-old singer forged her mother's name on a note claiming she was 18.

"At that time, you weren't allowed to say 'roll' because it was considered vulgar. So when Georgia Gibbs did her version, she renamed it 'Dance With Me, Henry' and it went to No. 1 on the pop charts," the singer recalled. The Gibbs song was one of several in the early rock era when white singers got hits by covering songs by black artists, often with sanitized lyrics.

After her 1955 debut, James toured with Otis' revue, sometimes earning only $10 a night. In 1959, she signed with Chicago's legendary Chess label, began cranking out the hits and going on tours with performers such as Bobby Vinton, Little Richard, Fats Domino, Gene Vincent, Jerry Lee Lewis and the Everly Brothers.

"We would travel on four buses to all the big auditoriums. And we had a lot of fun," she recalled in 1987.

James recorded a string of hits in the late 1950s and '60s including "Trust In Me," ''Something's Got a Hold On Me," ''Sunday Kind of Love," ''All I Could Do Was Cry," and of course, "At Last."

"(Chess Records founder) Leonard Chess was the most aware of anyone. He went up and down the halls of Chess announcing, 'Etta's crossed over! Etta's crossed over!' I still didn't know exactly what that meant, except that maybe more white people were listening to me. The Chess brothers kept saying how I was their first soul singer, that I was taking their label out of the old Delta blues, out of rock and into the modern era. Soul was the new direction," she wrote in her autobiography. "But in my mind, I was singing old style, not new."

In 1967, she cut one of the most highly regarded soul albums of all time, "Tell Mama," an earthy fusion of rock and gospel music featuring blistering horn arrangements, funky rhythms and a churchy chorus. A song from the album, "Security," was a top 40 single in 1968.

Her professional success, however, was balanced against personal demons, namely a drug addiction.

"I was trying to be cool," she told the AP in 1995, explaining what had led her to try heroin.

"I hung out in Harlem and saw Miles Davis and all the jazz cats," she continued. "At one time, my heavy role models were all druggies. Billie Holiday sang so groovy. Is that because she's on drugs? It was in my mind as a young person. I probably thought I was a young Billie Holiday, doing whatever came with that."

She was addicted to the drug for years, beginning in 1960, and it led to a harrowing existence that included time behind bars. It sapped her singing abilities and her money, eventually, almost destroying her career.

It would take her at least two decades to beat her drug problem. Her husband, Artis Mills, even went to prison for years, taking full responsibility for drugs during an arrest even though James was culpable.

"My management was suffering. My career was in the toilet. People tried to help, but I was hell-bent on getting high," she wrote of her drug habit in 1980.

She finally quit the habit and managed herself for a while, calling up small clubs and asking them, "Have you ever heard of Etta James?" in order to get gigs. Eventually, she got regular bookings ? even drawing Elizabeth Taylor as an audience member. In 1984, she was tapped to sing the national anthem at the Olympic Games in Los Angeles, and her career got the resurgent boost it needed, though she fought addiction again when she got hooked on painkillers in the late 1980s.

Drug addiction wasn't her only problem. She struggled with her weight, and often performed from a wheelchair as she got older and heavier. In the early 2000s, she had weight-loss surgery and shed some 200 pounds.

James performed well into her senior years, and it was "At Last" that kept bringing her the biggest ovations. The song was a perennial that never aged, and on Jan. 20, 2009, as crowds celebrated that ? at last ? an African-American had become president of the United States, the song played as the first couple danced.

But it was superstar Beyonce who serenaded the Obamas, not the legendary singer. Beyonce had portrayed James in "Cadillac Records," a big-screen retelling of Chess Records' heyday, and had started to claim "At Last" as her own.

An audio clip surfaced of James at a concert shortly after the inauguration, saying she couldn't stand the younger singer and that Beyonce had "no business singing my song." But she told the New York Daily News later that she was joking, even though she had been hurt that she did not get the chance to participate in the inauguration.

Upon hearing of her death, Beyonce released a statement on her website that read: "This is a huge loss. Etta James was one of the greatest vocalists of our time. I am so fortunate to have met such a queen. Her musical contributions will last a lifetime. Playing Etta James taught me so much about myself, and singing her music inspired me to be a stronger artist. When she effortlessly opened her mouth, you could hear her pain and triumph. Her deeply emotional way of delivering a song told her story with no filter. She was fearless, and had guts. She will be missed."

James did get her accolades over the years. She was inducted into the Rock Hall in 1993, captured a Grammy in 2003 for best contemporary blues album for "Let's Roll," one in 2004 for best traditional blues album for "Blues to the Bone" and one for best jazz vocal performance for 1994's "Mystery Lady: Songs of Billie Holiday." She was also awarded a special Grammy in 2003 for lifetime achievement and got a star on the Hollywood Walk of Fame.

Her health went into decline, however, and by 2011, she was being cared for at home by a personal doctor.

She suffered from dementia, kidney problems and leukemia. Her husband and her two sons fought over control of her $1 million estate, though a deal was later struck keeping Mills as the conservator and capping the singer's expenses at $350,000. In December 2011, her physician announced that her leukemia was terminal, and asked for prayers for the singer.

In October 2011, it was announced that James was retiring from recording, and a final studio recording, "The Dreamer," was released, featuring the singer taking on classic songs, from Bobby "Blue" Bland's "Dreamer" to Guns N' Roses "Welcome To the Jungle" ? still rocking, and a fitting end to her storied career.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-01-20-US-Obit-Etta-James/id-ad552b78769540b2ad7e772be59af08b

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Friday, January 20, 2012

Luke Bryan, Eric Church to headline ACM concerts

FILE - In this Nov. 9, 2011 file photo, Luke Bryan arrives at the 45th Annual CMA Awards in Nashville, Tenn. Bryan and Eric Church will perform March 30-31 at the Fremont Street Experience, the popular sixth annual show that's free to the public. Bryan will headline Friday's show and Church will handle Saturday. (AP Photo/Evan Agostini, file)

FILE - In this Nov. 9, 2011 file photo, Luke Bryan arrives at the 45th Annual CMA Awards in Nashville, Tenn. Bryan and Eric Church will perform March 30-31 at the Fremont Street Experience, the popular sixth annual show that's free to the public. Bryan will headline Friday's show and Church will handle Saturday. (AP Photo/Evan Agostini, file)

FILE - In this Nov. 9, 2011 file photo, singer Eric Church arrives at the 45th Annual CMA Awards in Nashville. Church and Luke Bryan will perform March 30-31 at the Fremont Street Experience, the popular sixth annual show that's free to the public. Bryan will headline Friday's show and Church will handle Saturday. (AP Photo/Evan Agostini, file)

(AP) ? Two of country music's hottest rising stars will headline The Academy of Country Music's annual weekend concerts in Las Vegas this year.

Luke Bryan and Eric Church will perform March 30-31 at the Fremont Street Experience, the popular sixth annual show that's free to the public. Bryan will headline Friday's show and Church will handle Saturday. The rest of the lineup will be announced later.

The ACM Awards follow on April 1, live from the MGM Grand and Mandalay Bay on CBS. Reba McEntire and Blake Shelton host.

Bryan and Church are coming off the most successful years of their careers. Church's "CHIEF" debuted at No. 1 on the Billboard Top 200 all genre chart, and Bryan's "tailgates & tanlines" hit No. 2.

___

Online:

http://www.acmcountry.com

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-01-20-Music-Bryan-Church/id-cc370712198d46c7b71d5d14fe2e324a

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Thursday, January 19, 2012

Jerry Yang Out at Yahoo! [Yahoo]

Yahoo! board member Jerry Yang has apparently been forced out of the company he founded. In a statement released today, Yahoo announced he had resigned from its board of directors, and all other positions at the company. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/8JbFOiFKneU/yahoo-kicks-founder-jerry-yang-to-the-curb

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Avalanches kill 14 in Afghanistan (AP)

KABUL, Afghanistan ? Avalanches caused by heavy snowfall have killed at least 14 people in a mountainous region in northeastern Afghanistan, officials said Tuesday.

Rescue crews were trying to reach the remote areas of Badakhshan province where a number of houses were reported to have been destroyed on Monday, said Shams ul-Rahman deputy provincial governor.

Between 6-9 feet (2-3 meters) of snow have fallen in the area, making roads to the provincial capital of Faizabad impassable.

"We have reports of at least 14 dead and several others injured," ul-Rahman said, adding that several other people were missing.

Avalanches present a constant danger in many parts of Afghanistan during the winter.

In February 2010, an avalanche killed at least 171 people near the 12,700-foot (3,800-meter) high Salang Pass, a major route through the Hindu Kush mountains that connects the Afghan capital of Kabul to the north of the country.

Meanwhile, Afghan President Hamid Karzai urged the Taliban to allow teams conducting a polio vaccination campaign access to areas under the insurgents' control.

Afghanistan is one of just three nations where polio remains endemic. The two others are Nigeria and neighboring Pakistan.

"Whoever prevents the polio vaccination is the enemy of our children's future," Karzai said in a statement.

Last year, the government registered 80 new cases of polio, most of them in the restive southern provinces. That figure was three times higher than the total for 2010.

The polio virus, which usually infects children in unsanitary conditions, attacks the central nervous system, sometimes causing paralysis, muscular atrophy, deformation and, in some cases, death.

"Karzai called on the armed opposition to the government to allow the medical teams to vaccinate the children and rescue them from polio," the government statement said.

Karzai said that although millions of Afghan children had been inoculated in successive vaccination campaigns, many remained outside the reach of health officials because of the security situation in areas in the south and along the border with Pakistan.

Karzai's appeal came just days after another country in the region, India, celebrated a full year since its last reported case of polio, a major victory in a global eradication effort.

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20120117/ap_on_re_as/as_afghanistan

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Wednesday, January 18, 2012

Solving the mystery of an old diabetes drug that may reduce cancer risk

Solving the mystery of an old diabetes drug that may reduce cancer risk [ Back to EurekAlert! ] Public release date: 18-Jan-2012
[ | E-mail | Share Share ]

Contact: Allison Flynn
allison.j.flynn@mcgill.ca
514-398-7698
McGill University

Research opens exciting new avenues in cancer prevention

In 2005, news first broke that researchers in Scotland found unexpectedly low rates of cancer among diabetics taking metformin, a drug commonly prescribed to patients with Type II diabetes. Many follow-up studies reported similar findings, some suggesting as much as a 50-per-cent reduction in risk.

How could this anti-diabetic drug reduce the risk of developing cancer and what were the mechanisms involved?

In a paper published today in the journal Cancer Prevention Research, researchers from McGill University and the University of Montreal reported an unexpected finding: they learned that exposure to metformin reduces the cellular mutation rate and the accumulation of DNA damage. It is well known that such mutations are directly involved in carcinogenesis, but lowering cancer risk by inhibiting the mutation rate has never been shown to be feasible.

"It is remarkable that metformin, an inexpensive, off-patent, safe and widely used drug, has several biological actions that may result in reduced cancer risk these latest findings suggest that it reduces mutation rate in somatic cells, providing an additional mechanism by which it could prevent cancer, explained Dr. Michael Pollak, professor in McGill's Departments of Medicine and Oncology, researcher at the Lady Davis Institute for Medical Research at the Jewish General Hospital and the study's director.

The study, carried out in collaboration with the laboratory of Dr. Gerardo Ferbeyre at Universit de Montral's Department of Biochemistry, suggests that metformin reduces DNA damage by reducing levels of reactive oxygen species (ROS). ROS are known to be DNA-damaging agents produced as by-products when cells generate energy from nutrients. This action appears to take place in mitochondria, the cellular organelles that produce energy in cells by "burning" nutrients. Past studies have identified the mitochondria as a site of action for metformin related to its anti-diabetic function, but those studies had not considered that the drug also acted here to reduce ROS production, thereby reducing the rate at which DNA damage accumulates. "We found that metformin did not act as a classic antioxidant," said Ferbeyre. "The drug seems to selectively prevent ROS production from altered mitochondria such as those found in cells with oncogenic mutations."

"This study opens an exciting new direction in cancer-prevention research," said Pollak. "This doesn't imply, however, that metformin is now ready to be widely used for cancer prevention. We do not yet know if the drug accumulates to sufficient concentrations in human tissues at risk for cancer, such as breast or colon, when taken at the usual doses used for diabetes treatment, nor do we know if the findings from the original studies showing reduced cancer risk, which were carried out in diabetics, also apply to people without diabetes. But the possibility of protecting DNA from oxidative damage by the use of a well-tolerated drug was not expected, and this topic now needs further study at many levels."

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Solving the mystery of an old diabetes drug that may reduce cancer risk [ Back to EurekAlert! ] Public release date: 18-Jan-2012
[ | E-mail | Share Share ]

Contact: Allison Flynn
allison.j.flynn@mcgill.ca
514-398-7698
McGill University

Research opens exciting new avenues in cancer prevention

In 2005, news first broke that researchers in Scotland found unexpectedly low rates of cancer among diabetics taking metformin, a drug commonly prescribed to patients with Type II diabetes. Many follow-up studies reported similar findings, some suggesting as much as a 50-per-cent reduction in risk.

How could this anti-diabetic drug reduce the risk of developing cancer and what were the mechanisms involved?

In a paper published today in the journal Cancer Prevention Research, researchers from McGill University and the University of Montreal reported an unexpected finding: they learned that exposure to metformin reduces the cellular mutation rate and the accumulation of DNA damage. It is well known that such mutations are directly involved in carcinogenesis, but lowering cancer risk by inhibiting the mutation rate has never been shown to be feasible.

"It is remarkable that metformin, an inexpensive, off-patent, safe and widely used drug, has several biological actions that may result in reduced cancer risk these latest findings suggest that it reduces mutation rate in somatic cells, providing an additional mechanism by which it could prevent cancer, explained Dr. Michael Pollak, professor in McGill's Departments of Medicine and Oncology, researcher at the Lady Davis Institute for Medical Research at the Jewish General Hospital and the study's director.

The study, carried out in collaboration with the laboratory of Dr. Gerardo Ferbeyre at Universit de Montral's Department of Biochemistry, suggests that metformin reduces DNA damage by reducing levels of reactive oxygen species (ROS). ROS are known to be DNA-damaging agents produced as by-products when cells generate energy from nutrients. This action appears to take place in mitochondria, the cellular organelles that produce energy in cells by "burning" nutrients. Past studies have identified the mitochondria as a site of action for metformin related to its anti-diabetic function, but those studies had not considered that the drug also acted here to reduce ROS production, thereby reducing the rate at which DNA damage accumulates. "We found that metformin did not act as a classic antioxidant," said Ferbeyre. "The drug seems to selectively prevent ROS production from altered mitochondria such as those found in cells with oncogenic mutations."

"This study opens an exciting new direction in cancer-prevention research," said Pollak. "This doesn't imply, however, that metformin is now ready to be widely used for cancer prevention. We do not yet know if the drug accumulates to sufficient concentrations in human tissues at risk for cancer, such as breast or colon, when taken at the usual doses used for diabetes treatment, nor do we know if the findings from the original studies showing reduced cancer risk, which were carried out in diabetics, also apply to people without diabetes. But the possibility of protecting DNA from oxidative damage by the use of a well-tolerated drug was not expected, and this topic now needs further study at many levels."

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-01/mu-stm011812.php

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